An Unusual Case: Intestinal Polyposis Coli

An unusual case of Cowden syndrome associated with ganglioneuromatous polyposis.

BACKGROUND Ganglioneuromatous polyposis (GP) is a very rare disorder which may be associated with other clinical manifestations and syndromes, such as Cowden syndrome, multiple endocrine neoplasia (MEN) type II and neurofibromatosis (NF) 1. The risk for malignant transformation of ganglioneuromas is unknown, and the combination of GP with colon cancer has been only very seldom reported. METHO...

A Case of Juvenile Polyposis Coli

80 Our patient is a 20-year-old white female who presented with a two-year history of intermittent rectal bleeding and iron deficiency anemia. She had no significant family history. A gastroenterologist initially evaluated her two years prior to the current presentation. In preparation for a scheduled colonoscopy at that time, she left the facility against medical advice because of difficulty i...

Intestinal Polyposis

Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation.

Adult stem cells define a cellular reserve with the unique capacity to replenish differentiated cells of a tissue throughout an organism's lifetime. Previous analysis has demonstrated that the adult Drosophila midgut is maintained by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli (Apc), a tumor suppressor gene conserved in ...

Cap polyposis--an unusual cause of diarrhoea.

'Cap polyposis' is a poorly recognised condition with distinct clinical, sigmoidoscopic, and pathological features that may be confused with other inflammatory conditions of the large intestine including pseudomembranous colitis and idiopathic chronic inflammatory bowel disease. The pathogenesis is unknown but on the basis of the characteristic histological appearances, which are similar to tho...